Ana Goidea’s Transcalar Design argues that architecture’s ecological crisis cannot be addressed through superficial biomorphism or incremental digital efficiency alone; it requires a deeper reorganisation of design thinking around scalar interdependence. Positioned between computational design, digital fabrication and biodesign, the dissertation proposes transcalarity as an organisational principle through which architectural systems may be understood as dynamic relations between material composition, fabrication logic, biological process, environmental exchange and building-scale performance. The thesis responds to the construction industry’s disproportionate contribution to energy use, carbon emissions and waste, suggesting that biological systems offer models of circularity, adaptation, distributed intelligence, self-organisation and functional integration. Its central contribution lies in translating these biological logics into research-by-design experiments. Pulp Faction develops a 3D-printed architectural column grown from fungal biocomposites, where microbial transformation fuses sawdust-based matter into a structural artefact. Meristem Wall explores a full-scale 3D-printed building envelope that mediates between interior habitation and surrounding ecosystems through complex geometry and multifunctional integration. Swarm Materialization investigates termite-like collective construction through clay deposition, real-time sensing and agent-based computational processes. Together, these experiments show that architecture can no longer treat matter as inert substance awaiting form; rather, matter becomes an active participant in design. Goidea’s case study therefore reframes sustainability as a homeodynamic architectural condition: one in which buildings are conceived not as static objects, but as evolving interfaces between human habitation, living systems and planetary consequence.